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Withanolide A:

Product Description

Product Name: Withanolide A
Botanical Source: Withania somnifera
IUPAC Name: (5a,6a,7a,22R)-6,7-epoxy-5,20,22-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic Acid d-Lactone
Synonyms: Withaniol
CAS Number: 32911-62-9 Chemical Structure:
Molecular Formula: C28H38O6
Molecular weight: 470.60
Appearance: White powder
Purity: >98%
HRMS (ESI): --
Specific Rotation [a]D 20:
Smiles: O=C(O1)C(C)=C(C)C[C@]1([H])[C@@](O)(C)[C@H]2CC[C@@]3([H])[C@]4([H])[C@H]5[C@H](O5)[C@@]([C@@]6(C)[C@@]4([H])CC[C@@]32C)(O)CC=CC6=O
InChI Code: InChI=1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-
InChI Key: 5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1DXWHOKCXBGLTMQ-SFQAJKIESA-N
MDL NUMBER: MFCD07779143
PubChem ID: 11294368
Inventory status: Available in gram quantities

Technical Note

Product Name: Withanolide A
CAS Number: 60124-17-6
Botanical Source: Withania somnifera
Functional Activity:
It has antioxidant and neuroprotective activity
It helps to promote neurite outgrowth at 1 M in cultured neurons
Reverses hypoxia-mediated neurodegeneration by restoring hypoxia-induced glutathione depletion in the hippocampus of mice
Chemical Structure:
Key References:
  1. Withanolide A Prevents Neurodegeneration by Modulating Hippocampal Glutathione Biosynthesis during Hypoxia. PLoS One, 2014,  9,  1-17 
  2. Profiling withanolide A for therapeutic targets in neurodegenerative diseases. Bioorg Med Chem.,  2019, 27, 2508-2520
  3. Natural Withanolides in the Treatment of Chronic Diseases. Adv Exp Med Biol.,  2016, 928, 329-373
  4. Neuritic regeneration and synaptic reconstruction induced by withanolide A. British Journal of Pharmacology, 2005,  144,  961-971 
  5. Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem.Pharm.Bull.(Tokyo), 2002,  50 , 760-765
  6. β-Amyloid1-42, HIV-1Bα-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS One, 2014,  9,  1-23
  7. Attenuation of Glutamate-Induced Excitotoxicity by Withanolide-A in Neuron-Like Cells: Role for PI3K/Akt/MAPK Signaling Pathway. Mol Neurobiol.,  2018, 55, 2725-2739
  8. Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans. Exp Gerontol,  2018, 104, 113-117
  9. Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer. Drug Des Devel Ther., 2017, 11, 1859-1870

Certificates of Analysis

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