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Withanone (CAS No: 27570-38-3) >98% by HPLC:

Product Description

Product Name: Withanone
Botanical Source: Withania somnifera
IUPAC Name: (22R)-6a,7a-Epoxy-5,17,22-trihydroxy-1-oxo-5a-ergosta-2,24-dien-26-oic acid d-lactone
Synonyms: NSC 179884
CAS Number: 27570-38-3 Chemical Structure:
Molecular Formula: C28H38O6
Molecular weight: 470.60
Appearance: White powder
Purity: >98%
HRMS (ESI): --
Specific Rotation [a]D 20:
Smiles: O=C1C=CC[C@]2(O)[C@@]3([H])O[C@@]3([H])[C@@]4([H])[C@]5([H])CC[C@](O)([C@@H]([C@H]6CC(C)=C(C)C(O6)=O)C)[C@@]5(C)CC[C@]4([H])[C@@]12C
InChI Code: InChI=1S/C28H38O6/c1-14-13-19(33-24(30)15(14)2)16(3)27(31)12-9-17-21-18(8-11-25(17,27)4)26(5)20(29)7-6-10-28(26,32)23-22(21)34-23/h6-7,16-19,21-23,31-32H,8-13H2,1-5H3/t16-,17+,18+,19-,21+,22+,23+,25+,26+,27+,28+/m1/s1
PubChem ID: 21679027
Inventory status: Available in gram quantities

Technical Note

Product Name: Withanone
CAS Number: 27570-38-3
Botanical Source: Withania somnifera
Functional Activity:
  • Withanone combined with Cucurbitacin B has selective toxicity to cancer cells
  • It is a potential candidate molecule in cancer therapy.
  • serve as potential neuroprotective agent
  • shows promise in Alzheimer's disease treatment because of cognitive benefits
  • significantly enhanced the acetyl choline and Glutathione (GSH) activity
Chemical Structure:
Key References:
  1. Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential. J Gerontol A Biol Sci Med Sci,. 2020, 75, 1031-1041
  2. Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence. Ann Neurosci. 2018, 25, 201-209
  3. Understanding ligands driven mechanism of wild and mutant aryl hydrocarbon receptor in presence of phytochemicals combating Parkinson's disease: an in silico and in vivo study. J Biomol Struct Dyn, . 2020, 38, 807-826
  4. Wild type p53 function in p53(Y220C) mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence. J Exp Clin Cancer Res. 2019, 38, 103
  5. Structural bioinformatics-based identification of putative plant based lead compounds for Alzheimer Disease Therapy. Comput Biol Chem. 2019, 78, 359-366
  6. Multifunctional neuroprotective effect of Withanone, a compound from Withania somnifera roots in alleviating cognitive dysfunction. Cytokine. 2018, 102, 211-221
  7. Withanolides against TLR4-Activated Innate Inflammatory Signalling Pathways: A Comparative Computational and Experimental Study. Phytother Res. 2017, 31, 152-163
  8. Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study. J Neuroinflammation. 2016, 13, 193
  9. Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells. Mol Neurobiol. 2017, 54, 5061-5073
  10. Withania somnifera aqueous extract facilitates the expression and release of GnRH: In vitro and in vivo study. Neurochem Int. 2015, 89, 111-119
  11. Deceleration of Senescence in Normal Human Fibroblasts by Withanone Extracted From Ashwagandha Leaves. The Journals of Gerontology: Series A, 2009, 64A, 1031–1038
  12. Composition for lifetime extension of normal cell containing withanone which is ingredient of leaf extract of withania somnifera. JP 2008 195704A

Certificates of Analysis

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